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ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway
The accumulation of damaged mitochondria causes the death of dopaminergic neurons. The Parkin-mediated mitophagy pathway functions to remove these mitochondria from cells. Targeting this pathway represents a therapeutic strategy for several neurodegenerative diseases, most notably Parkinson’s diseas...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6941965/ https://ncbi.nlm.nih.gov/pubmed/31900402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13781-3 |
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