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Autophagy Inhibitor LRPPRC Suppresses Mitophagy through Interaction with Mitophagy Initiator Parkin

Autophagy plays an important role in tumorigenesis. Mitochondrion-associated protein LRPPRC interacts with MAP1S that interacts with LC3 and bridges autophagy components with microtubules and mitochondria to affect autophagy flux. Dysfunction of LRPPRC and MAP1S is associated with poor survival of o...

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Detalhes bibliográficos
Main Authors: Zou, Jing, Yue, Fei, Li, Wenjiao, Song, Kun, Jiang, Xianhan, Yi, Jinglin, Liu, Leyuan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983268/
https://ncbi.nlm.nih.gov/pubmed/24722279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094903
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