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Adenylyl Cyclase 6 Expression Is Essential for Cholera Toxin–Induced Diarrhea

BACKGROUND: Cholera toxin (CT)–induced diarrhea is mediated by cyclic adenosine monophosphate (cAMP)–mediated active Cl(–) secretion via the cystic fibrosis transmembrane conductance regulator (CFTR). Although the constitutive activation of adenylyl cyclase (AC) in response to CT is due to adenosine...

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Bibliographische Detailangaben
Veröffentlicht in:J Infect Dis
Hauptverfasser: Fenton, Robert A, Murali, Sathish K, Kaji, Izumi, Akiba, Yasutada, Kaunitz, Jonathan D, Kristensen, Tina B, Poulsen, Søren B, Dominguez Rieg, Jessica A, Rieg, Timo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941499/
https://ncbi.nlm.nih.gov/pubmed/30624615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiz013
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