Adenylyl Cyclase 6 Expression Is Essential for Cholera Toxin–Induced Diarrhea

BACKGROUND: Cholera toxin (CT)–induced diarrhea is mediated by cyclic adenosine monophosphate (cAMP)–mediated active Cl(–) secretion via the cystic fibrosis transmembrane conductance regulator (CFTR). Although the constitutive activation of adenylyl cyclase (AC) in response to CT is due to adenosine...

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Библиографические подробности
Опубликовано в: :J Infect Dis
Главные авторы: Fenton, Robert A, Murali, Sathish K, Kaji, Izumi, Akiba, Yasutada, Kaunitz, Jonathan D, Kristensen, Tina B, Poulsen, Søren B, Dominguez Rieg, Jessica A, Rieg, Timo
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2019
Предметы:
Major Articles and Brief Reports
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941499/
https://ncbi.nlm.nih.gov/pubmed/30624615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiz013
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