Adenylyl Cyclase 6 Expression Is Essential for Cholera Toxin–Induced Diarrhea

BACKGROUND: Cholera toxin (CT)–induced diarrhea is mediated by cyclic adenosine monophosphate (cAMP)–mediated active Cl(–) secretion via the cystic fibrosis transmembrane conductance regulator (CFTR). Although the constitutive activation of adenylyl cyclase (AC) in response to CT is due to adenosine...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Fenton, Robert A, Murali, Sathish K, Kaji, Izumi, Akiba, Yasutada, Kaunitz, Jonathan D, Kristensen, Tina B, Poulsen, Søren B, Dominguez Rieg, Jessica A, Rieg, Timo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941499/
https://ncbi.nlm.nih.gov/pubmed/30624615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiz013
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