Adenylyl Cyclase 6 Expression Is Essential for Cholera Toxin–Induced Diarrhea

BACKGROUND: Cholera toxin (CT)–induced diarrhea is mediated by cyclic adenosine monophosphate (cAMP)–mediated active Cl(–) secretion via the cystic fibrosis transmembrane conductance regulator (CFTR). Although the constitutive activation of adenylyl cyclase (AC) in response to CT is due to adenosine...

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Détails bibliographiques
Publié dans:J Infect Dis
Auteurs principaux: Fenton, Robert A, Murali, Sathish K, Kaji, Izumi, Akiba, Yasutada, Kaunitz, Jonathan D, Kristensen, Tina B, Poulsen, Søren B, Dominguez Rieg, Jessica A, Rieg, Timo
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Major Articles and Brief Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941499/
https://ncbi.nlm.nih.gov/pubmed/30624615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiz013
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