Teleost IgD(+)IgM(−) B Cells Mount Clonally Expanded and Mildly Mutated Intestinal IgD Responses in the Absence of Lymphoid Follicles

Immunoglobulin D (IgD) is an ancient antibody with dual membrane-bound and fluid-phase antigen receptor functions. The biology of secreted IgD remains elusive. Here, we demonstrate that teleost IgD(+)IgM(−) plasmablasts constitute a major lymphocyte population in some mucosal surfaces, including the...

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Pubblicato in:Cell Rep
Autori principali: Perdiguero, Pedro, Martín-Martín, Alba, Benedicenti, Ottavia, Díaz-Rosales, Patricia, Morel, Esther, Muñoz-Atienza, Estefanía, García-Flores, Mónica, Simón, Rocío, Soleto, Irene, Cerutti, Andrea, Tafalla, Carolina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941218/
https://ncbi.nlm.nih.gov/pubmed/31875534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.11.101
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