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Unexpected Racemization in the Course of the Acetalization of (+)-(S)-5-Methyl-Wieland–Miescher Ketone with 1,2-Ethanediol and TsOH under Classical Experimental Conditions

(+)-(S) and (−)-(R)-5-methyl-Wieland-Miescher ketone (+)-1 and (−)-1, are important synthons in the diastereo and enantioselective syntheses of biological and/or pharmacological interesting compounds. A key step in these syntheses is the chemoselective C(1)O acetalization to (+)-5 and (−)-5, respect...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Leonelli, Francesca, Piergentili, Irene, Lucarelli, Giulio, Migneco, Luisa Maria, Marini Bettolo, Rinaldo
Format: Artigo
Langue:Inglês
Publié: MDPI 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941009/
https://ncbi.nlm.nih.gov/pubmed/31817544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20246147
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