The human T-cell leukemia virus type-1 Tax oncoprotein dissociates NF-κB p65(RelA) Stathmin complexes and causes catastrophic mitotic spindle damage and genomic instability

Genomic instability is a hallmark of many cancers; however, the molecular etiology of chromosomal dysregulation is not well understood. The human T-cell leukemia virus type-1 (HTLV-1) oncoprotein Tax activates NF-κB-signaling and induces DNA-damage and aberrant chromosomal segregation through divers...

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Publicat a:Virology
Autors principals: Malu, Aditi, Hutchison, Tetiana, Yapindi, Laçin, Smith, Katie, Nelson, Katherine, Bergeson, Rachel, Pope, Jordan, Romeo, Megan, Harrod, Carolyn, Ratner, Lee, Lint, Carine Van, Harrod, Robert
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940561/
https://ncbi.nlm.nih.gov/pubmed/31299491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2019.07.003
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