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Anti-CD40 antibody 2C10 binds to a conformational epitope at the CD40-CD154 interface that is conserved among primate species

The antagonistic anti-CD40 antibody, 2C10, and its recombinant primate derivative, 2C10R4, are potent immunosuppressive antibodies whose utility in allo- and xenotransplantation have been demonstrated in nonhuman primate studies. In this study, we defined the 2C10 binding epitope and found only slig...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Transplant
Prif Awduron: Michaels, Anthony J., Stoppato, Matteo, Flores, Walter J., Reimann, Keith A., Engelman, Kathleen D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940519/
https://ncbi.nlm.nih.gov/pubmed/31430418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.15574
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