Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary

Sclerosing stromal tumor (SST) of the ovary is a rare type of sex cord-stromal tumor (SCST), whose genetic underpinning is currently unknown. Here, using whole-exome, targeted capture and RNA-sequencing, we report recurrent FHL2-GLI2 fusion genes in 65% (17/26) of SSTs and other GLI2 rearrangements...

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Publié dans:Nat Commun
Auteurs principaux: Kim, Sarah H., Da Cruz Paula, Arnaud, Basili, Thais, Dopeso, Higinio, Bi, Rui, Pareja, Fresia, da Silva, Edaise M., Gularte-Mérida, Rodrigo, Sun, Zhen, Fujisawa, Sho, Smith, Caitlin G., Ferrando, Lorenzo, Martins Sebastião, Ana Paula, Bykov, Yonina, Li, Anqi, Silveira, Catarina, Ashley, Charles W., Stylianou, Anthe, Selenica, Pier, Samore, Wesley R., Jungbluth, Achim A., Zamarin, Dmitriy, Abu-Rustum, Nadeem R., Helin, Kristian, Soslow, Robert A., Reis-Filho, Jorge S., Oliva, Esther, Weigelt, Britta
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940380/
https://ncbi.nlm.nih.gov/pubmed/31896750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13806-x
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