Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration

Upon severe or chronic liver injury, adult ductal cells (cholangiocytes) contribute to regeneration by restoring both hepatocytes and cholangiocytes. Recently, we showed that ductal cells clonally expand as self-renewing liver organoids that retain their differentiation capacity into both hepatocyte...

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Vydáno v:Nat Cell Biol
Hlavní autoři: Aloia, Luigi, McKie, Mikel Alexander, Vernaz, Grégoire, Cordero-Espinoza, Lucía, Aleksieva, Niya, van den Ameele, Jelle, Antonica, Francesco, Font-Cunill, Berta, Raven, Alexander, Aiese Cigliano, Riccardo, Belenguer, German, Mort, Richard L., Brand, Andrea H., Zernicka-Goetz, Magdalena, Forbes, Stuart J., Miska, Eric A., Huch, Meritxell
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940196/
https://ncbi.nlm.nih.gov/pubmed/31685987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0402-6
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