Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration

Upon severe or chronic liver injury, adult ductal cells (cholangiocytes) contribute to regeneration by restoring both hepatocytes and cholangiocytes. Recently, we showed that ductal cells clonally expand as self-renewing liver organoids that retain their differentiation capacity into both hepatocyte...

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Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Aloia, Luigi, McKie, Mikel Alexander, Vernaz, Grégoire, Cordero-Espinoza, Lucía, Aleksieva, Niya, van den Ameele, Jelle, Antonica, Francesco, Font-Cunill, Berta, Raven, Alexander, Aiese Cigliano, Riccardo, Belenguer, German, Mort, Richard L., Brand, Andrea H., Zernicka-Goetz, Magdalena, Forbes, Stuart J., Miska, Eric A., Huch, Meritxell
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940196/
https://ncbi.nlm.nih.gov/pubmed/31685987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0402-6
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