A unified mechanism for intron and exon definition and back-splicing

The molecular mechanisms of exon definition and back-splicing are fundamental unanswered questions in pre-mRNA splicing. Here we report cryoEM structures of the yeast E complex assembled on introns, providing the first view of the earliest event in the splicing cycle that commits pre-mRNAs to splici...

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Vydáno v:Nature
Hlavní autoři: Li, Xueni, Liu, Shiheng, Zhang, Lingdi, Issaian, Aaron, Hill, Ryan C., Espinosa, Sara, Shi, Shasha, Cui, Yanxiang, Kappel, Kalli, Das, Rhiju, Hansen, Kirk C., Zhou, Z. Hong, Zhao, Rui
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939996/
https://ncbi.nlm.nih.gov/pubmed/31485080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1523-6
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