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A unified mechanism for intron and exon definition and back-splicing
The molecular mechanisms of exon definition and back-splicing are fundamental unanswered questions in pre-mRNA splicing. Here we report cryoEM structures of the yeast E complex assembled on introns, providing the first view of the earliest event in the splicing cycle that commits pre-mRNAs to splici...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6939996/ https://ncbi.nlm.nih.gov/pubmed/31485080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1523-6 |
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