One week of continuous corticosterone exposure impairs hepatic metabolic flexibility, promotes islet β-cell proliferation, and reduces physical activity in male C57BL/6J mice

Clinical glucocorticoid use, and diseases that produce elevated circulating glucocorticoids, promote drastic changes in body composition and reduction in whole body insulin sensitivity. Because steroid-induced diabetes is the most common form of drug-induced hyperglycemia, we investigated mechanisms...

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Pubblicato in:J Steroid Biochem Mol Biol
Autori principali: Burke, Susan J., Batdorf, Heidi M., Huang, Tai-Yu, Jackson, Joseph W., Jones, Katarina A., Martin, Thomas M., Rohli, Kristen E., Karlstad, Michael D., Sparer, Tim E., Burk, David H., Campagna, Shawn R., Noland, Robert C., Soto, Paul L., Collier, J. Jason
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939671/
https://ncbi.nlm.nih.gov/pubmed/31536768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2019.105468
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