Inhibition of CDK4/6 by Palbociclib Significantly Extends Survival in Medulloblastoma Patient-Derived Xenograft Mouse Models

PURPOSE: Bioinformatics analysis followed by in vivo studies in patient-derived xenograft models were used to identify and validate CDK 4/6 inhibition as an effective therapeutic strategy for medulloblastoma, particularly Group 3 MYC-amplified tumors which have the worst clinical prognosis. EXPERIME...

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發表在:Clin Cancer Res
Main Authors: Cook Sangar, Michelle L., Genovesi, Laura A., Nakamoto, Madison W., Davis, Melissa J., Knobluagh, Sue E., Ji, Pengxiang, Millar, Amanda, Wainwright, Brandon J., Olson, James M.
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939669/
https://ncbi.nlm.nih.gov/pubmed/28637687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-2943
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