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A fluorogenic RNA-based sensor activated by metabolite-induced RNA dimerization
Corn is a fluorogenic RNA aptamer that forms a high-affinity quasi-symmetric homodimer. The Corn dimer interface binds DFHO, resulting in highly photostable yellow fluorescence. Because of its photostability, Corn would be useful in RNA-based small molecule biosensors, where quantitative accuracy wo...
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| Izdano u: | Cell Chem Biol |
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| Glavni autori: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6939632/ https://ncbi.nlm.nih.gov/pubmed/31631009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.09.013 |
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