Migratory DCs activate TGF-β to precondition naive CD8(+) T cells for tissue-resident memory fate

Epithelial resident memory T (eT(RM)) cells serve as sentinels in barrier tissues to guard against previously encountered pathogens. How eT(RM) cells are generated has significant implications for efforts to elicit their formation through vaccination or prevent it in autoimmune disease. Here we show...

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Publicado en:Science
Autores principales: Mani, Vinidhra, Bromley, Shannon K., Äijö, Tarmo, Mora-Buch, Rut, Carrizosa, Esteban, Warner, Ross D., Hamze, Moustafa, Sen, Debattama R., Chasse, Alexandra Y., Lorant, Alina, Griffith, Jason W., Rahimi, Rod A., McEntee, Craig P., Jeffrey, Kate L., Marangoni, Francesco, Travis, Mark A., Lacy-Hulbert, Adam, Luster, Andrew D., Mempel, Thorsten R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939608/
https://ncbi.nlm.nih.gov/pubmed/31601741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav5728
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