Inhibition of sphingosine 1-phosphate lyase activates human keratinocyte differentiation and attenuates psoriasis in mice

Sphingosine 1-phosphate (S1P) lyase is an intracellular enzyme that catalyzes the irreversible degradation of S1P and has been suggested as a therapeutic target for the treatment of psoriasis vulgaris. Because S1P induces differentiation of keratinocytes, we examined whether modulation of S1P lyase...

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Dettagli Bibliografici
Pubblicato in:J Lipid Res
Autori principali: Jeon, Suwon, Song, Jaehwi, Lee, Dongyup, Kim, Goon-Tae, Park, Si-Hyun, Shin, Dong-Yoon, Shin, Kyong-Oh, Park, Kyungho, Shim, Soon-Mi, Park, Tae-Sik
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939600/
https://ncbi.nlm.nih.gov/pubmed/31690639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000254
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