Genetic heterogeneity of BRAF fusion kinases in melanoma affects drug responses

BRAF fusions are detected in numerous neoplasms but their clinical management remains unresolved. We identified six melanoma lines harboring BRAF fusions representative of the clinical cases reported in the literature. Their unexpected heterogeneous responses to RAF and MEK inhibitors could be categ...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Botton, Thomas, Talevich, Eric, Mishra, Vivek Kumar, Zhang, Tongwu, Shain, A. Hunter, Berquet, Céline, Gagnon, Alexander, Judson, Robert L., Ballotti, Robert, Ribas, Antoni, Herlyn, Meenhard, Rocchi, Stéphane, Brown, Kevin M., Hayward, Nicholas K., Yeh, Iwei, Bastian, Boris C.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939448/
https://ncbi.nlm.nih.gov/pubmed/31618628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.09.009
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