Genetic heterogeneity of BRAF fusion kinases in melanoma affects drug responses

BRAF fusions are detected in numerous neoplasms but their clinical management remains unresolved. We identified six melanoma lines harboring BRAF fusions representative of the clinical cases reported in the literature. Their unexpected heterogeneous responses to RAF and MEK inhibitors could be categ...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Botton, Thomas, Talevich, Eric, Mishra, Vivek Kumar, Zhang, Tongwu, Shain, A. Hunter, Berquet, Céline, Gagnon, Alexander, Judson, Robert L., Ballotti, Robert, Ribas, Antoni, Herlyn, Meenhard, Rocchi, Stéphane, Brown, Kevin M., Hayward, Nicholas K., Yeh, Iwei, Bastian, Boris C.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939448/
https://ncbi.nlm.nih.gov/pubmed/31618628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.09.009
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker