Genetic heterogeneity of BRAF fusion kinases in melanoma affects drug responses

BRAF fusions are detected in numerous neoplasms but their clinical management remains unresolved. We identified six melanoma lines harboring BRAF fusions representative of the clinical cases reported in the literature. Their unexpected heterogeneous responses to RAF and MEK inhibitors could be categ...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Botton, Thomas, Talevich, Eric, Mishra, Vivek Kumar, Zhang, Tongwu, Shain, A. Hunter, Berquet, Céline, Gagnon, Alexander, Judson, Robert L., Ballotti, Robert, Ribas, Antoni, Herlyn, Meenhard, Rocchi, Stéphane, Brown, Kevin M., Hayward, Nicholas K., Yeh, Iwei, Bastian, Boris C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939448/
https://ncbi.nlm.nih.gov/pubmed/31618628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.09.009
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