Mechanisms of Nanonewton Mechanostability in a Protein Complex Revealed by Molecular Dynamics Simulations and Single-Molecule Force Spectroscopy

[Image: see text] Can molecular dynamics simulations predict the mechanical behavior of protein complexes? Can simulations decipher the role of protein domains of unknown function in large macromolecular complexes? Here, we employ a wide-sampling computational approach to demonstrate that molecular...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Bernardi, Rafael C., Durner, Ellis, Schoeler, Constantin, Malinowska, Klara H., Carvalho, Bruna G., Bayer, Edward A., Luthey-Schulten, Zaida, Gaub, Hermann E., Nash, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939381/
https://ncbi.nlm.nih.gov/pubmed/31464132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b06776
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