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Beyond Protein Binding: Recent Advances In Screening DNA-Encoded Libraries

DNA-encoded library (DEL) screening has emerged as an important method for early stage drug and probe molecule discovery. The vast majority of screens using DELs have been relatively simple binding assays. The library is incubated with a target molecule, which is almost always a protein, and the DNA...

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Detalhes bibliográficos
Publicado no:Chem Commun (Camb)
Main Authors: Kodadek, Thomas, Paciaroni, Nicholas G., Balzarini, Madeline, Dickson, Paige
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939232/
https://ncbi.nlm.nih.gov/pubmed/31633708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cc06256d
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