CFTR Therapeutics Normalize Cerebral Perfusion Deficits in Mouse Models of Heart Failure and Subarachnoid Hemorrhage

Heart failure (HF) and subarachnoid hemorrhage (SAH) chronically reduce cerebral perfusion, which negatively affects clinical outcome. This work demonstrates a strong relationship between cerebral artery cystic fibrosis transmembrane conductance regulator (CFTR) expression and altered cerebrovascula...

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Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Lidington, Darcy, Fares, Jessica C., Uhl, Franziska E., Dinh, Danny D., Kroetsch, Jeffrey T., Sauvé, Meghan, Malik, Firhan A., Matthes, Frank, Vanherle, Lotte, Adel, Arman, Momen, Abdul, Zhang, Hangjun, Aschar-Sobbi, Roozbeh, Foltz, Warren D., Wan, Hoyee, Sumiyoshi, Manabu, Macdonald, R. Loch, Husain, Mansoor, Backx, Peter H., Heximer, Scott P., Meissner, Anja, Bolz, Steffen-Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939007/
https://ncbi.nlm.nih.gov/pubmed/31909302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2019.07.004
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