PRSS contributes to cetuximab resistance in colorectal cancer

Cetuximab improves the survival of patients with metastatic colorectal cancer. The main limitation is primary and secondary resistance, the underlying mechanism of which requires extensive investigation. We proved that PRSS expression levels are significantly negatively associated with the sensitivi...

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Gepubliceerd in:Sci Adv
Hoofdauteurs: Tan, Zhaoli, Gao, Lihua, Wang, Yan, Yin, Huihui, Xi, Yongyi, Wu, Xiaojie, Shao, Yong, Qiu, Weiyi, Du, Peng, Shen, Wenlong, Fu, Ling, Jia, Ru, Zhao, Chuanhua, Zhang, Yun, Zhao, Zhihu, Sun, Zhiwei, Chen, Hongxing, Hu, Xianwen, Xu, Jianming, Wang, Youliang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Association for the Advancement of Science 2020
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938705/
https://ncbi.nlm.nih.gov/pubmed/31911942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax5576
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