PRSS contributes to cetuximab resistance in colorectal cancer

Cetuximab improves the survival of patients with metastatic colorectal cancer. The main limitation is primary and secondary resistance, the underlying mechanism of which requires extensive investigation. We proved that PRSS expression levels are significantly negatively associated with the sensitivi...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Tan, Zhaoli, Gao, Lihua, Wang, Yan, Yin, Huihui, Xi, Yongyi, Wu, Xiaojie, Shao, Yong, Qiu, Weiyi, Du, Peng, Shen, Wenlong, Fu, Ling, Jia, Ru, Zhao, Chuanhua, Zhang, Yun, Zhao, Zhihu, Sun, Zhiwei, Chen, Hongxing, Hu, Xianwen, Xu, Jianming, Wang, Youliang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2020
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938705/
https://ncbi.nlm.nih.gov/pubmed/31911942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax5576
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