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Differential impact of two critical respiratory centers in opioid-induced respiratory depression in awake mice

The primary cause of death from opioid overdose is respiratory failure. High doses of opioids cause severe rate depression and increased risk of fatal apnea, which correlate with increasing irregularities in breathing pattern. Mu opioid receptors (MORs) are widely distributed throughout the brainste...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Varga, Adrienn G., Reid, Brandon T., Kieffer, Brigitte L., Levitt, Erica S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938533/
https://ncbi.nlm.nih.gov/pubmed/31589332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP278612
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