A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans

We performed a hypothesis-generating phenome-wide association study (PheWAS) to identify and characterize cross-phenotype associations, where one SNP is associated with two or more phenotypes, between thousands of genetic variants assayed on the Metabochip and hundreds of phenotypes in 5,897 African...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Pendergrass, Sarah A., Buyske, Steven, Jeff, Janina M., Frase, Alex, Dudek, Scott, Bradford, Yuki, Ambite, Jose-Luis, Avery, Christy L., Buzkova, Petra, Deelman, Ewa, Fesinmeyer, Megan D., Haiman, Christopher, Heiss, Gerardo, Hindorff, Lucia A., Hsu, Chun-Nan, Jackson, Rebecca D., Lin, Yi, Le Marchand, Loic, Matise, Tara C., Monroe, Kristine R., Moreland, Larry, North, Kari E., Park, Sungshim L., Reiner, Alex, Wallace, Robert, Wilkens, Lynne R., Kooperberg, Charles, Ritchie, Marylyn D., Crawford, Dana C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938343/
https://ncbi.nlm.nih.gov/pubmed/31891604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226771
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