The Use of Phenome-Wide Association Studies (PheWAS) for Exploration of Novel Genotype-Phenotype Relationships and Pleiotropy Discovery

The field of phenomics has been investigating network structure among large arrays of phenotypes, and genome-wide association studies (GWAS) have been used to investigate the relationship between genetic variation and single diseases/outcomes. A novel approach has emerged combining both the explorat...

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Autori principali: Pendergrass, S.A., Brown-Gentry, K., Dudek, S.M., Torstenson, E.S., Ambite, J.L., Avery, C.L., Buyske, S., Cai, C., Fesinmeyer, M.D., Haiman, C., Heiss, G., Hindorff, L.A., Hsu, C.-N., Jackson, R.D., Kooperberg, C., Le Marchand, L., Lin, Y., Matise, T.C., Moreland, L., Monroe, K., Reiner, A.P., Wallace, R., Wilkens, L.R., Crawford, D.C., Ritchie, M.D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116446/
https://ncbi.nlm.nih.gov/pubmed/21594894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.20589
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