Longitudinal monitoring of KRAS-mutated circulating tumor DNA enables the prediction of prognosis and therapeutic responses in patients with pancreatic cancer

BACKGROUND: Liquid biopsies enable the detection of circulating tumor DNA (ctDNA). However, the clinical significance of KRAS-mutated ctDNA for pancreatic cancer has been inconsistent with respect to its prognostic and predictive potential. METHODS AND FINDINGS: A total of 422 blood samples were col...

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Veröffentlicht in:PLoS One
Hauptverfasser: Watanabe, Fumiaki, Suzuki, Koichi, Tamaki, Sawako, Abe, Iku, Endo, Yuhei, Takayama, Yuji, Ishikawa, Hideki, Kakizawa, Nao, Saito, Masaaki, Futsuhara, Kazushige, Noda, Hiroshi, Konishi, Fumio, Rikiyama, Toshiki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938323/
https://ncbi.nlm.nih.gov/pubmed/31891652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227366
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