Tankyrase inhibition sensitizes cells to CDK4 blockade

Tankyrase (TNKS) 1/2 are positive regulators of WNT signaling by controlling the activity of the ß-catenin destruction complex. TNKS inhibitors provide an opportunity to suppress hyperactive WNT signaling in tumors, however, they have shown limited anti-proliferative activity as a monotherapy in hum...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Foronda, Miguel, Tarumoto, Yusuke, Schatoff, Emma M., Leach, Benjamin I., Diaz, Bianca J., Zimmerman, Jill, Goswami, Sukanya, Shusterman, Michael, Vakoc, Christopher R., Dow, Lukas E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938305/
https://ncbi.nlm.nih.gov/pubmed/31891587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226645
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