Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway

BACKGROUND: Signaling pathways critical for embryonic development re-emerge in adult pancreas during tumorigenesis. Aspartate β-hydroxylase (ASPH) drives embryonic cell motility/invasion in pancreatic development/differentiation. We explored if dysregulated ASPH is critically involved in pancreatic...

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Publicado en:J Hematol Oncol
Main Authors: Ogawa, Kosuke, Lin, Qiushi, Li, Le, Bai, Xuewei, Chen, Xuesong, Chen, Hua, Kong, Rui, Wang, Yongwei, Zhu, Hong, He, Fuliang, Xu, Qinggang, Liu, Lianxin, Li, Min, Zhang, Songhua, Nagaoka, Katsuya, Carlson, Rolf, Safran, Howard, Charpentier, Kevin, Sun, Bei, Wands, Jack, Dong, Xiaoqun
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2019
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937817/
https://ncbi.nlm.nih.gov/pubmed/31888763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-019-0837-z
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