α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

Alpha-synuclein inclusions, the hallmarks of synucleinopathies, are suggested to spread along neuronal connections in a stereotypical pattern in the brains of patients. Ample evidence now supports that pathological forms of alpha-synuclein propagate in cell culture models and in vivo in a prion-like...

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Vydáno v:Acta Neuropathol Commun
Hlavní autoři: Rey, Nolwen L., Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer A., Melki, Ronald, Brundin, Patrik
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937797/
https://ncbi.nlm.nih.gov/pubmed/31888771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0859-3
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