Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure–Activity Relationships

[Image: see text] Lysyl oxidase (LOX) is a secreted copper-dependent amine oxidase that cross-links collagens and elastin in the extracellular matrix and is a critical mediator of tumor growth and metastatic spread. LOX is a target for cancer therapy, and thus the search for therapeutic agents again...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Leung, Leo, Niculescu-Duvaz, Dan, Smithen, Deborah, Lopes, Filipa, Callens, Cedric, McLeary, Robert, Saturno, Grazia, Davies, Lawrence, Aljarah, Mohammed, Brown, Michael, Johnson, Louise, Zambon, Alfonso, Chambers, Tim, Ménard, Delphine, Bayliss, Natasha, Knight, Ruth, Fish, Laura, Lawrence, Rae, Challinor, Mairi, Tang, HaoRan, Marais, Richard, Springer, Caroline
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2019
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937593/
https://ncbi.nlm.nih.gov/pubmed/31070916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00335
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