Phosphorylation of the multifunctional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2

B-cell adaptor protein (BCAP) is a multimodular, multifunctional signal transducer that regulates signal transduction pathways in leukocytes, including macrophages, B-cells, and T-cells. In particular, BCAP suppresses inflammatory signaling by Toll-like receptors (TLRs). However, how BCAP itself is...

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Vydáno v:J Biol Chem
Hlavní autoři: Lauenstein, Johannes U., Udgata, Atul, Bartram, Alex, De Sutter, Delphine, Fisher, David I., Halabi, Samer, Eyckerman, Sven, Gay, Nicholas J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937578/
https://ncbi.nlm.nih.gov/pubmed/31527084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009931
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