Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation

Expression of human leukocyte antigen (HLA)-B27 is strongly associated with predisposition toward ankylosing spondylitis (AS) and other spondyloarthropathies. However, the exact involvement of HLA-B27 in disease initiation and progression remains unclear. The homodimer theory, which proposes that HL...

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Udgivet i:J Biol Chem
Main Authors: Lim Kam Sian, Terry C. C., Indumathy, Saranjah, Halim, Hanim, Greule, Anja, Cryle, Max J., Bowness, Paul, Rossjohn, Jamie, Gras, Stephanie, Purcell, Anthony W., Schittenhelm, Ralf B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937573/
https://ncbi.nlm.nih.gov/pubmed/31740583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010257
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