Wnt family member 4 (WNT4) and WNT3A activate cell-autonomous Wnt signaling independent of porcupine O-acyltransferase or Wnt secretion

Porcupine O-acyltransferase (PORCN) is considered essential for Wnt secretion and signaling. However, we observed that PORCN inhibition does not phenocopy the effects of WNT4 knockdown in WNT4-dependent breast cancer cells. This suggests a unique relationship between PORCN and WNT4 signaling. To exa...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Rao, Deviyani M., Shackleford, Madeleine T., Bordeaux, Evelyn K., Sottnik, Joseph L., Ferguson, Rebecca L., Yamamoto, Tomomi M., Wellberg, Elizabeth A., Bitler, Benjamin G., Sikora, Matthew J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937561/
https://ncbi.nlm.nih.gov/pubmed/31740580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009615
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