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An in vitro fatty acylation assay reveals a mechanism for Wnt recognition by the acyltransferase Porcupine

Wnt proteins are a family of secreted signaling proteins that play key roles in regulating cell proliferation in both embryonic and adult tissues. Production of active Wnt depends on attachment of palmitoleate, a monounsaturated fatty acid, to a conserved serine by the acyltransferase Porcupine (POR...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Principais autores: Asciolla, James J., Miele, Matthew M., Hendrickson, Ronald C., Resh, Marilyn D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566510/
https://ncbi.nlm.nih.gov/pubmed/28655768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C117.800136
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