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An in vitro fatty acylation assay reveals a mechanism for Wnt recognition by the acyltransferase Porcupine
Wnt proteins are a family of secreted signaling proteins that play key roles in regulating cell proliferation in both embryonic and adult tissues. Production of active Wnt depends on attachment of palmitoleate, a monounsaturated fatty acid, to a conserved serine by the acyltransferase Porcupine (POR...
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| Veröffentlicht in: | J Biol Chem |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5566510/ https://ncbi.nlm.nih.gov/pubmed/28655768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C117.800136 |
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