Untargeted Adductomics of Newborn Dried Blood Spots Identifies Modifications to Human Serum Albumin Associated with Childhood Leukemia

The developing fetus is exposed to chemicals, which are metabolized to electrophiles that form adducts with nucleophilic Cys34 of human serum albumin (HSA). By measuring these adducts in neonatal blood spots (NBS), we obtain information regarding fetal exposures during the last month of gestation. T...

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Bibliographic Details
Published in:Leuk Res
Main Authors: Yano, Yukiko, Schiffman, Courtney, Grigoryan, Hasmik, Hayes, Josie, Edmands, William, Petrick, Lauren, Whitehead, Todd, Metayer, Catherine, Dudoit, Sandrine, Rappaport, Stephen
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937378/
https://ncbi.nlm.nih.gov/pubmed/31760269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2019.106268
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