Untargeted Adductomics of Newborn Dried Blood Spots Identifies Modifications to Human Serum Albumin Associated with Childhood Leukemia

The developing fetus is exposed to chemicals, which are metabolized to electrophiles that form adducts with nucleophilic Cys34 of human serum albumin (HSA). By measuring these adducts in neonatal blood spots (NBS), we obtain information regarding fetal exposures during the last month of gestation. T...

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Veröffentlicht in:Leuk Res
Hauptverfasser: Yano, Yukiko, Schiffman, Courtney, Grigoryan, Hasmik, Hayes, Josie, Edmands, William, Petrick, Lauren, Whitehead, Todd, Metayer, Catherine, Dudoit, Sandrine, Rappaport, Stephen
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937378/
https://ncbi.nlm.nih.gov/pubmed/31760269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2019.106268
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