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Reversal of increased mammary tumorigenesis by valproic acid and hydralazine in offspring of dams fed high fat diet during pregnancy

Maternal or paternal high fat (HF) diet can modify the epigenome in germ cells and fetal somatic cells leading to an increased susceptibility among female offspring of multiple generations to develop breast cancer. We determined if combined treatment with broad spectrum DNA methyltransferase (DNMT)...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Andrade, F. de Oliveira, Nguyen, N. M., Warri, A., Hilakivi-Clarke, L.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937280/
https://ncbi.nlm.nih.gov/pubmed/31889127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56854-5
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