Oral administration of EP4-selective agonist KAG-308 suppresses mouse knee osteoarthritis development through reduction of chondrocyte hypertrophy and TNF secretion

Osteoarthritis (OA) is one of the world’s most common degenerative diseases, but there is no disease-modifying treatment available. Previous studies have shown that prostaglandin E2 (PGE(2)) and PGE2 receptor 4 (EP(4)) are involved in OA pathogenesis; however, their roles are not fully understood. H...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Murahashi, Yasutaka, Yano, Fumiko, Chijimatsu, Ryota, Nakamoto, Hideki, Maenohara, Yuji, Amakawa, Masahiro, Miyake, Yoshihide, Yamanaka, Hiroyuki, Iba, Kousuke, Yamashita, Toshihiko, Tanaka, Sakae, Saito, Taku
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937271/
https://ncbi.nlm.nih.gov/pubmed/31889132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56861-6
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