Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease

Although mouse models of Alzheimer’s disease (AD) have provided tremendous breakthroughs, the etiology of later onset AD remains unknown. In particular, tau pathology in the association cortex is poorly replicated in mouse models. Aging rhesus monkeys naturally develop cognitive deficits, amyloid pl...

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Arnsten, Amy F. T., Datta, Dibyadeep, Leslie, Shannon, Yang, Sheng-Tao, Wang, Min, Nairn, Angus C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2019
Aiheet:
Arthur M. Sackler Colloquium Using Monkey Models to Understand and Develop Treatments for Human Brain Disorders
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936707/
https://ncbi.nlm.nih.gov/pubmed/31871209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903671116
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