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5-HT(2A) receptor activation normalizes stress-induced dysregulation of GABAergic signaling in the ventral tegmental area

Stress is known to alter GABAergic signaling in the ventral tegmental area (VTA), and this inhibitory plasticity is associated with increased alcohol self-administration. In humans, serotonin 2A receptor (5-HT(2A)R) agonists can treat stress- and alcohol-related disorders, but the neural substrates...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kimmey, Blake A., Ostroumov, Alexey, Dani, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936697/
https://ncbi.nlm.nih.gov/pubmed/31806759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911446116
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