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5-HT(2A) receptor activation normalizes stress-induced dysregulation of GABAergic signaling in the ventral tegmental area

Stress is known to alter GABAergic signaling in the ventral tegmental area (VTA), and this inhibitory plasticity is associated with increased alcohol self-administration. In humans, serotonin 2A receptor (5-HT(2A)R) agonists can treat stress- and alcohol-related disorders, but the neural substrates...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Kimmey, Blake A., Ostroumov, Alexey, Dani, John A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936697/
https://ncbi.nlm.nih.gov/pubmed/31806759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911446116
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