Loss of p57(KIP2) expression confers resistance to contact inhibition in human androgenetic trophoblast stem cells

A complete hydatidiform mole (CHM) is androgenetic in origin and characterized by enhanced trophoblastic proliferation and the absence of fetal tissue. In 15 to 20% of cases, CHMs are followed by malignant gestational trophoblastic neoplasms including choriocarcinoma. Aberrant genomic imprinting may...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Takahashi, Sota, Okae, Hiroaki, Kobayashi, Norio, Kitamura, Akane, Kumada, Kanako, Yaegashi, Nobuo, Arima, Takahiro
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2019
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936680/
https://ncbi.nlm.nih.gov/pubmed/31792181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1916019116
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