Targeted Depletion of Primary Cilia in Dopaminoceptive Neurons in a Preclinical Mouse Model of Huntington’s Disease

Multiple pathomechanisms triggered by mutant Huntingtin (mHTT) underlie progressive degeneration of dopaminoceptive striatal neurons in Huntington’s disease (HD). The primary cilium is a membrane compartment that functions as a hub for various pathways that are dysregulated in HD, for example, dopam...

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Vydáno v:Front Cell Neurosci
Hlavní autoři: Mustafa, Rasem, Kreiner, Grzegorz, Kamińska, Katarzyna, Wood, Amelia-Elise J., Kirsch, Joachim, Tucker, Kerry L., Parlato, Rosanna
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Cellular Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936315/
https://ncbi.nlm.nih.gov/pubmed/31920562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00565
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