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Vaccine-driven virulence evolution: consequences of unbalanced reductions in mortality and transmission and implications for pertussis vaccines

Many vaccines have heterogeneous effects across individuals. Additionally, some vaccines do not prevent infection, but reduce disease-associated mortality and transmission. Both of these factors will alter selection pressures on pathogens and thus shape the evolution of pathogen virulence. We use a...

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Bibliografiske detaljer
Udgivet i:J R Soc Interface
Main Authors: Miller, Ian F., Metcalf, C. Jessica
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936036/
https://ncbi.nlm.nih.gov/pubmed/31822219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2019.0642
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