Automatic Identification of Individual rpoB Gene Mutations Responsible for Rifampin Resistance in Mycobacterium tuberculosis by Use of Melting Temperature Signatures Generated by the Xpert MTB/RIF Ultra Assay

Molecular surveillance of rifampin-resistant Mycobacterium tuberculosis can help to monitor the transmission of the disease. The Xpert MTB/RIF Ultra assay detects mutations in the rifampin resistance-determining region (RRDR) of the rpoB gene by the use of melting temperature (T(m)) information from...

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Udgivet i:J Clin Microbiol
Main Authors: Cao, Yuan, Parmar, Heta, Simmons, Ann Marie, Kale, Devika, Tong, Kristy, Lieu, Deanna, Persing, David, Kwiatkowski, Robert, Alland, David, Chakravorty, Soumitesh
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Mycobacteriology and Aerobic Actinomycetes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6935902/
https://ncbi.nlm.nih.gov/pubmed/31533985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.00907-19
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