A carregar...
ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophy
Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by homozygous mutation or deletion of the survival motor neuron 1 (SMN1) gene. A second copy, SMN2, is similar to SMN1 but produces ∼10% SMN protein because of a single-point mutation that causes splicing defects. Chronic low levels of...
Na minha lista:
| Publicado no: | Brain |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2020
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6935747/ https://ncbi.nlm.nih.gov/pubmed/31828288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awz373 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|