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Minding the gap: the impact of B-cell tolerance on the microbial antibody repertoire

B lymphocytes must respond to vast numbers of foreign antigens, including those of microbial pathogens. To do so, developing B cells use combinatorial joining of V-, D-, and J-gene segments to generate an extraordinarily diverse repertoire of B-cell antigen receptors (BCRs). Unsurprisingly, a large...

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Dades bibliogràfiques
Publicat a:Immunol Rev
Autors principals: Finney, Joel, Watanabe, Akiko, Kelsoe, Garnett, Kuraoka, Masayuki
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6935408/
https://ncbi.nlm.nih.gov/pubmed/31559648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imr.12805
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