Self-tolerance curtails the B cell repertoire to microbial epitopes

Immunological tolerance removes or inactivates self-reactive B cells, including those that also recognize cross-reactive foreign antigens. Whereas a few microbial pathogens exploit these “holes” in the B cell repertoire by mimicking host antigens to evade immune surveillance, the extent to which tol...

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Bibliographische Detailangaben
Veröffentlicht in:JCI Insight
Hauptverfasser: Watanabe, Akiko, Su, Kuei-Ying, Kuraoka, Masayuki, Yang, Guang, Reynolds, Alexander E., Schmidt, Aaron G., Harrison, Stephen C., Haynes, Barton F., St. Clair, E. William, Kelsoe, Garnett
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542615/
https://ncbi.nlm.nih.gov/pubmed/31092727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122551
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