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A Modified Peptide Derived from Goodpasture Autoantigen Arrested and Attenuated Kidney Injuries in a Rat Model of Anti-GBM Glomerulonephritis
BACKGROUND: In Goodpasture disease, the noncollagenous domain 1 of the α3 chain (α3NC1) of type IV collagen is the main target antigen of antibodies against glomerular basement membrane (GBM). We previously identified a nephritogenic epitope, P14 (α3(127–148)), that could induce crescentic nephritis...
Enregistré dans:
| Publié dans: | J Am Soc Nephrol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Nephrology
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6935000/ https://ncbi.nlm.nih.gov/pubmed/31666297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019010067 |
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